Adolescent HPV Vaccination: A U.S. and Global Perspective on Overcoming Barriers

Authors

  • Valeria Gutierrez Garcia Massachusetts General Hospital and Harvard Medical School Author
  • Rachel Mpanumpanu University of Miami School of Medicine, Obstetrics, Gynecology and Reproductive Sciences Author
  • Asha Ciara Sneed University of Maryland School of Medicine Author
  • Natalie Romero University of Miami School of Medicine, Obstetrics, Gynecology and Reproductive Sciences Author
  • Lunthita M. Duthely University of Miami School of Medicine, Obstetrics, Gynecology and Reproductive Sciences Author

DOI:

https://doi.org/10.65638/2978-882X.2025.01.10

Keywords:

HPV, Human papillomavirus, Vaccination, Immunization disparities, Cancer prevention, Adolescent health, global health equity

Abstract

Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States and a major contributor to preventable cancers, including cervical, anal, and oropharyngeal cancers, with consequences for individual and population wellbeing. Despite the availability of effective vaccines, HPV vaccination rates remain significantly lower than those for other adolescent immunizations. This health equity-focused editorial explores key factors contributing to low vaccine uptake, including age-based recommendations, testing limitations, affordability, and structural barriers to access. Regional and gender disparities within the U.S., coupled with stark global differences between high-income and low- and middle-income countries, highlight the urgent need for targeted strategies. Improving HPV vaccination coverage requires a multifaceted approach, combining public education, provider advocacy, and capacity building to ensure equitable access. Addressing these gaps is essential to reduce HPV-related disease burden, improve population wellbeing and advance global health equity.

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2025-12-24

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